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doi: 10.1371/journal.pone.0058700 39 TakH.NegiS.GuptaA.GanapathiT

Holopainen-Mantila, J

During development and progression of atherosclerosis, Nrf2 signaling modulates many physiological and pathophysiological processes, like regulation of lipid homeostasis, CD36 gene expression regulation, foam cell formation, macrophage polarization, immunity regulation (Th2 differentiation and inhibition of pro-inflammatory gene expression through NFB down-regulation), redox regulation and inflammation, improvement of endothelial dysfunction, as well as GSH synthesis and utilization (234245)

Hao et al., 2022)

By dissolving under the tongue, the glutathione is delivered more directly into the systemic circulation, potentially allowing for quicker onset of action and increased bioavailability compared to traditional oral dosage forms